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O75874

Isocitrate dehydrogenase [NADP] cytoplasmic (O75874)

Uniprot ID O75874
Protein Name Isocitrate dehydrogenase [NADP] cytoplasmic
Gene Name IDH1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.598
Function
GO - Molecular function
  • cadherin binding : HDA:BHF-UCL
  • identical protein binding : IPI:IntAct
  • isocitrate dehydrogenase (NADP+) activity : IDA:UniProtKB
  • magnesium ion binding : IDA:UniProtKB
  • NAD binding : IEA:InterPro
  • NADP binding : IEA:Ensembl
  • protein homodimerization activity : IPI:UniProtKB
GO - Biological process
  • 2-oxoglutarate metabolic process : IDA:UniProtKB
  • female gonad development : IEA:Ensembl
  • glutathione metabolic process : IEA:Ensembl
  • glyoxylate cycle : IEA:UniProtKB-KW
  • isocitrate metabolic process : IDA:UniProtKB
  • NADP metabolic process : IBA:GO_Central
  • NADPH regeneration : TAS:Reactome
  • neutrophil degranulation : TAS:Reactome
  • protein targeting to peroxisome : TAS:Reactome
  • regulation of phospholipid biosynthetic process : IEA:Ensembl
  • regulation of phospholipid catabolic process : IEA:Ensembl
  • response to oxidative stress : IEA:Ensembl
  • response to steroid hormone : IEA:Ensembl
  • tricarboxylic acid cycle : IEA:UniProtKB-KW
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.