| Signal peptide(a) |
N |
Secretome P(b) |
0.406 |
| Function |
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity). . |
| GO - Molecular function |
- DNA-binding transcription factor activity, RNA polymerase II-specific : ISA:NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding : IBA:GO_Central
- RNA polymerase II transcription factor binding : IBA:GO_Central
- sequence-specific DNA binding : IBA:GO_Central
|
| GO - Biological process |
- aging : IEA:Ensembl
- anatomical structure morphogenesis : IBA:GO_Central
- animal organ morphogenesis : TAS:ProtInc
- cellular response to glial cell derived neurotrophic factor : IEA:Ensembl
- dopaminergic neuron differentiation : ISS:UniProtKB
- lens development in camera-type eye : ISS:UniProtKB
- lens morphogenesis in camera-type eye : ISS:UniProtKB
- midbrain development : ISS:UniProtKB
- negative regulation of gliogenesis : IEA:Ensembl
- positive regulation of cell proliferation in midbrain : IEA:Ensembl
- positive regulation of neuron apoptotic process : IEA:Ensembl
- positive regulation of transcription, DNA-templated : ISS:UniProtKB
- regulation of transcription, DNA-templated : ISS:UniProtKB
- response to cocaine : IEA:Ensembl
- response to immobilization stress : IEA:Ensembl
- response to methamphetamine hydrochloride : IEA:Ensembl
- response to morphine : IEA:Ensembl
|