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O60462

Neuropilin-2 (O60462)

Uniprot ID O60462
Protein Name Neuropilin-2
Gene Name NRP2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.516
Function High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. .
GO - Molecular function
  • cytokine binding : NAS:BHF-UCL
  • growth factor binding : TAS:BHF-UCL
  • heparin binding : IEA:UniProtKB-KW
  • identical protein binding : IPI:IntAct
  • metal ion binding : IEA:UniProtKB-KW
  • semaphorin receptor activity : NAS:UniProtKB
  • signaling receptor activity : TAS:ProtInc
  • vascular endothelial growth factor-activated receptor activity : TAS:ProtInc
GO - Biological process
  • angiogenesis : NAS:UniProtKB
  • axon extension involved in axon guidance : ISS:BHF-UCL
  • axon guidance : TAS:ProtInc
  • cell adhesion : NAS:UniProtKB
  • cellular response to leukemia inhibitory factor : IEA:Ensembl
  • dorsal root ganglion morphogenesis : IEA:Ensembl
  • facial nerve structural organization : IEA:Ensembl
  • facioacoustic ganglion development : IEA:Ensembl
  • gonadotrophin-releasing hormone neuronal migration to the hypothalamus : IEA:Ensembl
  • negative chemotaxis : IEA:Ensembl
  • nerve development : ISS:BHF-UCL
  • neural crest cell migration involved in autonomic nervous system development : IEA:Ensembl
  • outflow tract septum morphogenesis : ISS:BHF-UCL
  • positive regulation of endothelial cell migration : TAS:BHF-UCL
  • positive regulation of endothelial cell proliferation : TAS:BHF-UCL
  • regulation of postsynapse organization : IEA:Ensembl
  • semaphorin-plexin signaling pathway involved in neuron projection guidance : ISS:BHF-UCL
  • sensory neuron axon guidance : IEA:Ensembl
  • sympathetic ganglion development : ISS:BHF-UCL
  • sympathetic neuron projection extension : ISS:BHF-UCL
  • sympathetic neuron projection guidance : ISS:BHF-UCL
  • trigeminal ganglion development : IEA:Ensembl
  • vascular endothelial growth factor receptor signaling pathway : TAS:Reactome
  • ventral trunk neural crest cell migration : IEA:Ensembl
  • vestibulocochlear nerve structural organization : IEA:Ensembl
  • viral process : IEA:UniProtKB-KW
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.