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O60383

Growth/differentiation factor 9 (O60383)

Uniprot ID O60383
Protein Name Growth/differentiation factor 9
Gene Name GDF9
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.863
Function Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. .
GO - Molecular function
  • cytokine activity : IBA:GO_Central
  • growth factor activity : TAS:ProtInc
  • transforming growth factor beta receptor binding : IBA:GO_Central
GO - Biological process
  • BMP signaling pathway : IBA:GO_Central
  • cell development : IBA:GO_Central
  • female gamete generation : TAS:ProtInc
  • negative regulation of cell growth : IEA:Ensembl
  • oocyte growth : IEA:Ensembl
  • positive regulation of cell population proliferation : IDA:UniProtKB
  • positive regulation of pathway-restricted SMAD protein phosphorylation : IBA:GO_Central
  • regulation of apoptotic process : IBA:GO_Central
  • regulation of MAPK cascade : IBA:GO_Central
  • regulation of progesterone secretion : IDA:UniProtKB
  • SMAD protein signal transduction : IBA:GO_Central
  • transforming growth factor beta receptor signaling pathway : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.