Tolloid-like protein 1 (O43897)

Uniprot ID O43897
Protein Name Tolloid-like protein 1
Gene Name TLL1
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.48
Function Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
GO - Molecular function
  • calcium ion binding : IEA:InterPro
  • metalloendopeptidase activity : IEA:InterPro
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • cell differentiation : IEA:UniProtKB-KW
  • extracellular matrix disassembly : TAS:Reactome
  • skeletal system development : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.