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O43766

Lipoyl synthase, mitochondrial (O43766)

Uniprot ID O43766
Protein Name Lipoyl synthase, mitochondrial
Gene Name LIAS
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.695
Function Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. .
GO - Molecular function
  • 4 iron, 4 sulfur cluster binding : IEA:UniProtKB-UniRule
  • lipoate synthase activity : ISS:UniProtKB
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • cellular nitrogen compound metabolic process : TAS:Reactome
  • inflammatory response : ISS:UniProtKB
  • lipoate biosynthetic process : ISS:UniProtKB
  • neural tube closure : IEA:Ensembl
  • protein lipoylation : IEA:UniProtKB-UniRule
  • response to lipopolysaccharide : ISS:UniProtKB
  • response to oxidative stress : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.