| Signal peptide(a) |
N |
Secretome P(b) |
0.46 |
| Function |
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). . |
| GO - Molecular function |
- centromeric DNA binding : TAS:ProtInc
|
| GO - Biological process |
- cell division : IEA:UniProtKB-KW
- endoplasmic reticulum to Golgi vesicle-mediated transport : IMP:HGNC-UCL
- establishment of mitotic spindle orientation : IMP:UniProtKB
- Golgi organization : IMP:UniProtKB
- meiotic cell cycle : TAS:ProtInc
- mitotic cell cycle checkpoint : IDA:UniProtKB
- mitotic metaphase plate congression : IMP:UniProtKB
- mitotic sister chromatid segregation : IDA:HGNC-UCL
- mitotic spindle assembly checkpoint : IBA:GO_Central
- protein localization to kinetochore : IMP:UniProtKB
- protein transport : IEA:UniProtKB-KW
- protein-containing complex assembly : IDA:HGNC-UCL
- regulation of exit from mitosis : IDA:HGNC-UCL
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum : TAS:Reactome
|