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O35737

Heterogeneous nuclear ribonucleoprotein H (O35737)

Uniprot ID O35737
Protein Name Heterogeneous nuclear ribonucleoprotein H
Gene Name Hnrnph1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.369
Function This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) (By similarity). .
GO - Molecular function
  • RNA binding : ISS:UniProtKB
GO - Biological process
  • mRNA processing : IEA:UniProtKB-KW
  • regulation of RNA splicing : ISS:UniProtKB
  • RNA splicing : IEA:UniProtKB-KW
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.