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O35567

Bifunctional purine biosynthesis protein PURH (O35567)

Uniprot ID O35567
Protein Name Bifunctional purine biosynthesis protein PURH
Gene Name Atic
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. .Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:25687571}.
GO - Molecular function
  • IMP cyclohydrolase activity : IDA:RGD
  • phosphoribosylaminoimidazolecarboxamide formyltransferase activity : IDA:RGD
  • protein homodimerization activity : ISS:UniProtKB
GO - Biological process
  • 'de novo' IMP biosynthetic process : IDA:RGD
  • animal organ regeneration : IEP:RGD
  • brainstem development : IEP:RGD
  • cellular response to interleukin-7 : ISO:RGD
  • cerebellum development : IEP:RGD
  • cerebral cortex development : IEP:RGD
  • cobalamin metabolic process : TAS:RGD
  • dihydrofolate metabolic process : IDA:RGD
  • nucleoside metabolic process : IDA:RGD
  • response to inorganic substance : IEP:RGD
  • ribonucleotide metabolic process : IDA:RGD
  • tetrahydrofolate biosynthetic process : IDA:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.