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O35474

EGF-like repeat and discoidin I-like domain-containing protein 3 (O35474)

Uniprot ID O35474
Protein Name EGF-like repeat and discoidin I-like domain-containing protein 3
Gene Name Edil3
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (5) Interactions
Signal peptide(a) Y Secretome P(b) 0.753
Function Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
GO - Molecular function
  • calcium ion binding : IEA:InterPro
  • integrin binding : IEA:InterPro
GO - Biological process
  • cell adhesion : IEA:UniProtKB-KW
  • multicellular organism development : IEA:UniProtKB-KW
  • positive regulation of cell-substrate adhesion : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.