Lysosomal thioesterase PPT2 (O35448)

Uniprot ID O35448
Protein Name Lysosomal thioesterase PPT2
Gene Name Ppt2
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.879
Function Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short-and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity). .
GO - Molecular function
  • palmitoyl hydrolase activity : ISO:MGI
  • palmitoyl-(protein) hydrolase activity : IEA:InterPro
GO - Biological process
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.