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O35298

Acyloxyacyl hydrolase (O35298)

Uniprot ID O35298
Protein Name Acyloxyacyl hydrolase
Gene Name Aoah
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) Y Secretome P(b) 0.607
Function Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPS) (PubMed:12810692, PubMed:15155618, PubMed:17322564, PubMed:19860560). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (PubMed:17322564, PubMed:19860560, PubMed:28622363). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (PubMed:18779055). .
GO - Molecular function
  • acyloxyacyl hydrolase activity : IDA:MGI
  • calcium ion binding : IDA:UniProtKB
GO - Biological process
  • fatty acid metabolic process : ISS:UniProtKB
  • lipopolysaccharide catabolic process : ISS:UniProtKB
  • lipopolysaccharide metabolic process : IDA:MGI
  • negative regulation of inflammatory response : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.