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O35215

D-dopachrome decarboxylase (O35215)

Uniprot ID O35215
Protein Name D-dopachrome decarboxylase
Gene Name Ddt
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (2) Interactions
Signal peptide(a) N Secretome P(b) 0.806
Function Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). .
GO - Molecular function
  • cytokine receptor binding : ISO:MGI
  • D-dopachrome decarboxylase activity : IEA:UniProtKB-EC
  • phenylpyruvate tautomerase activity : ISO:MGI
  • protease binding : IPI:BHF-UCL
GO - Biological process
  • melanin biosynthetic process : IEA:UniProtKB-KW
  • negative regulation of macrophage chemotaxis : ISO:MGI
  • positive regulation of ERK1 and ERK2 cascade : ISO:MGI
  • positive regulation of inflammatory response : IMP:BHF-UCL
  • positive regulation of tumor necrosis factor production : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.