Laminin subunit alpha-5 (O15230)

Uniprot ID O15230
Protein Name Laminin subunit alpha-5
Gene Name LAMA5
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.424
Function Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
GO - Molecular function
  • integrin binding : IDA:UniProtKB
GO - Biological process
  • animal organ morphogenesis : IBA:GO_Central
  • branching involved in salivary gland morphogenesis : IEA:Ensembl
  • branching involved in ureteric bud morphogenesis : IEA:Ensembl
  • cell migration : IDA:UniProtKB
  • cell-cell adhesion : IBA:GO_Central
  • cilium assembly : IEA:Ensembl
  • cytokine-mediated signaling pathway : TAS:Reactome
  • extracellular matrix organization : TAS:Reactome
  • hair follicle development : IEA:Ensembl
  • integrin-mediated signaling pathway : IMP:UniProtKB
  • lung development : IEA:Ensembl
  • morphogenesis of a polarized epithelium : IBA:GO_Central
  • morphogenesis of embryonic epithelium : IEA:Ensembl
  • muscle organ development : IEA:Ensembl
  • neural crest cell migration : IEA:Ensembl
  • odontogenesis of dentin-containing tooth : IEA:Ensembl
  • protein localization to plasma membrane : IEA:Ensembl
  • regulation of cell adhesion : IEA:InterPro
  • regulation of cell migration : IEA:InterPro
  • regulation of cell population proliferation : IEA:Ensembl
  • regulation of embryonic development : IEA:InterPro
  • substrate adhesion-dependent cell spreading : IDA:BHF-UCL
  • tissue development : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.