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O15123

Angiopoietin-2 (O15123)

Uniprot ID O15123
Protein Name Angiopoietin-2
Gene Name ANGPT2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.671
Function Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. .
GO - Molecular function
  • metal ion binding : IEA:UniProtKB-KW
  • receptor tyrosine kinase binding : IPI:UniProtKB
  • signaling receptor binding : TAS:ProtInc
GO - Biological process
  • angiogenesis : IEA:UniProtKB-KW
  • animal organ regeneration : IEA:Ensembl
  • cellular response to growth factor stimulus : IEA:Ensembl
  • germ cell development : IEA:Ensembl
  • glomerulus vasculature development : ISS:UniProtKB
  • leukocyte migration : TAS:Reactome
  • maternal process involved in female pregnancy : IEA:Ensembl
  • negative regulation of angiogenesis : IEA:Ensembl
  • negative regulation of blood vessel endothelial cell migration : IDA:UniProtKB
  • negative regulation of cell-substrate adhesion : IEA:Ensembl
  • negative regulation of positive chemotaxis : IDA:UniProtKB
  • positive regulation of angiogenesis : IEA:Ensembl
  • response to activity : IEA:Ensembl
  • response to glucose : IEA:Ensembl
  • response to hypoxia : IEA:Ensembl
  • response to mechanical stimulus : IEA:Ensembl
  • response to organic cyclic compound : IEA:Ensembl
  • response to radiation : IEA:Ensembl
  • signal transduction : TAS:ProtInc
  • Tie signaling pathway : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.