| Signal peptide(a) |
N |
Secretome P(b) |
0.5 |
| Function |
Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity). . |
| GO - Molecular function |
- chemorepellent activity : IBA:GO_Central
- semaphorin receptor binding : IBA:GO_Central
|
| GO - Biological process |
- branching involved in blood vessel morphogenesis : ISS:UniProtKB
- negative chemotaxis : IBA:GO_Central
- negative regulation of angiogenesis : ISS:UniProtKB
- negative regulation of axon extension involved in axon guidance : IBA:GO_Central
- negative regulation of cell-matrix adhesion : ISS:UniProtKB
- neural crest cell migration : IBA:GO_Central
- positive regulation of cell migration : IBA:GO_Central
- regulation of actin cytoskeleton reorganization : ISS:UniProtKB
- regulation of cell shape : ISS:UniProtKB
- semaphorin-plexin signaling pathway : ISS:UniProtKB
- sprouting angiogenesis : ISS:UniProtKB
- synapse organization : ISS:UniProtKB
|