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O14974

Protein phosphatase 1 regulatory subunit 12A (O14974)

Uniprot ID O14974
Protein Name Protein phosphatase 1 regulatory subunit 12A
Gene Name PPP1R12A
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.381
Function Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. .
GO - Molecular function
  • 14-3-3 protein binding : IDA:UniProtKB
  • enzyme inhibitor activity : IDA:UniProtKB
  • phosphatase regulator activity : IDA:UniProtKB
  • protein kinase binding : IPI:UniProtKB
GO - Biological process
  • cellular response to drug : IEA:Ensembl
  • centrosome cycle : IMP:UniProtKB
  • mitotic cell cycle : IMP:UniProtKB
  • negative regulation of catalytic activity : IDA:UniProtKB
  • positive regulation of myosin-light-chain-phosphatase activity : IMP:UniProtKB
  • positive regulation of transcription by RNA polymerase II : IDA:UniProtKB
  • protein dephosphorylation : IMP:UniProtKB
  • regulation of cell adhesion : IDA:UniProtKB
  • regulation of myosin-light-chain-phosphatase activity : IDA:UniProtKB
  • regulation of nucleocytoplasmic transport : IEA:Ensembl
  • signal transduction : IEA:InterPro
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.