Neuropilin-1 (O14786)

Uniprot ID	O14786
Protein Name	Neuropilin-1
Gene Name	NRP1
Species	Homo sapiens (Human)

Signal peptide^(a)	N	Secretome P^(b)	0.395
Function	Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins (PubMed:9288753, PubMed:9529250, PubMed:10688880). It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB (PubMed:9288753, PubMed:9529250, PubMed:10688880). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799). .[Isoform 2]: Binds VEGF-165 and may inhibit its binding to cells (PubMed:10748121, PubMed:26503042). May induce apoptosis by sequestering VEGF-165 (PubMed:10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. {ECO:0000269\|PubMed:10748121, ECO:0000269\|PubMed:26503042}.
GO - Molecular function	coreceptor activity : TAS:BHF-UCL cytokine binding : NAS:BHF-UCL growth factor binding : IPI:UniProtKB GTPase activator activity : IMP:BHF-UCL heparin binding : IEA:UniProtKB-KW metal ion binding : IEA:UniProtKB-KW protein kinase binding : IEA:Ensembl semaphorin receptor activity : NAS:BHF-UCL vascular endothelial growth factor binding : IPI:BHF-UCL vascular endothelial growth factor-activated receptor activity : ISS:BHF-UCL
GO - Biological process	actin cytoskeleton reorganization : IMP:BHF-UCL angiogenesis : IMP:BHF-UCL angiogenesis involved in coronary vascular morphogenesis : ISS:BHF-UCL animal organ morphogenesis : TAS:ProtInc artery morphogenesis : ISS:BHF-UCL axon extension involved in axon guidance : ISS:BHF-UCL axon guidance : TAS:ProtInc axonal fasciculation : IEA:Ensembl axonogenesis involved in innervation : ISS:BHF-UCL basal dendrite arborization : ISS:ARUK-UCL basal dendrite development : ISS:ARUK-UCL branching involved in blood vessel morphogenesis : ISS:BHF-UCL branchiomotor neuron axon guidance : IEA:Ensembl cell migration involved in sprouting angiogenesis : ISS:BHF-UCL cell-cell signaling : TAS:ProtInc cellular response to hepatocyte growth factor stimulus : IMP:BHF-UCL cellular response to vascular endothelial growth factor stimulus : ISS:BHF-UCL commissural neuron axon guidance : ISS:BHF-UCL coronary artery morphogenesis : IEA:Ensembl dichotomous subdivision of terminal units involved in salivary gland branching : IEA:Ensembl dorsal root ganglion morphogenesis : IEA:Ensembl endothelial cell chemotaxis : IMP:BHF-UCL endothelial cell migration : IMP:BHF-UCL endothelial tip cell fate specification : ISS:BHF-UCL facial nerve structural organization : IEA:Ensembl facioacoustic ganglion development : IEA:Ensembl gonadotrophin-releasing hormone neuronal migration to the hypothalamus : IEA:Ensembl hepatocyte growth factor receptor signaling pathway : IMP:BHF-UCL integrin-mediated signaling pathway : IMP:BHF-UCL motor neuron migration : ISS:UniProtKB negative regulation of axon extension involved in axon guidance : IEA:Ensembl negative regulation of extrinsic apoptotic signaling pathway : IEA:Ensembl negative regulation of neuron apoptotic process : IEA:Ensembl nerve development : ISS:BHF-UCL neural crest cell migration involved in autonomic nervous system development : ISS:BHF-UCL neuron migration : ISS:BHF-UCL neuropilin signaling pathway : IMP:BHF-UCL otic placode development : IEA:Ensembl outflow tract septum morphogenesis : ISS:BHF-UCL platelet-derived growth factor receptor signaling pathway : IMP:BHF-UCL positive chemotaxis : ISS:BHF-UCL positive regulation of actin cytoskeleton reorganization : IMP:BHF-UCL positive regulation of axon extension involved in axon guidance : ISS:BHF-UCL positive regulation of cell migration involved in sprouting angiogenesis : IEA:Ensembl positive regulation of cytokine activity : TAS:BHF-UCL positive regulation of endothelial cell migration : IMP:BHF-UCL positive regulation of endothelial cell proliferation : TAS:BHF-UCL positive regulation of ERK1 and ERK2 cascade : ISS:BHF-UCL positive regulation of filopodium assembly : IMP:BHF-UCL positive regulation of focal adhesion assembly : IDA:BHF-UCL positive regulation of peptidyl-tyrosine phosphorylation : IMP:BHF-UCL positive regulation of phosphorylation : IMP:BHF-UCL positive regulation of retinal ganglion cell axon guidance : ISS:BHF-UCL positive regulation of smooth muscle cell migration : TAS:BHF-UCL positive regulation of stress fiber assembly : IMP:BHF-UCL positive regulation of substrate adhesion-dependent cell spreading : IMP:BHF-UCL postsynapse organization : IEA:Ensembl protein localization to early endosome : ISS:BHF-UCL regulation of Cdc42 protein signal transduction : IMP:BHF-UCL regulation of retinal ganglion cell axon guidance : ISS:BHF-UCL regulation of vesicle-mediated transport : TAS:BHF-UCL renal artery morphogenesis : IEA:Ensembl response to wounding : IEA:Ensembl retina vasculature morphogenesis in camera-type eye : ISS:BHF-UCL retinal ganglion cell axon guidance : ISS:BHF-UCL semaphorin-plexin signaling pathway : NAS:BHF-UCL semaphorin-plexin signaling pathway involved in axon guidance : IEA:Ensembl semaphorin-plexin signaling pathway involved in neuron projection guidance : ISS:BHF-UCL sensory neuron axon guidance : IEA:Ensembl signal transduction : TAS:ProtInc sprouting angiogenesis : ISS:BHF-UCL substrate adhesion-dependent cell spreading : IMP:BHF-UCL substrate-dependent cell migration, cell extension : IMP:BHF-UCL sympathetic ganglion development : ISS:BHF-UCL sympathetic neuron projection extension : ISS:BHF-UCL sympathetic neuron projection guidance : ISS:BHF-UCL toxin transport : IEA:Ensembl trigeminal ganglion development : IEA:Ensembl trigeminal nerve structural organization : IEA:Ensembl vascular endothelial growth factor receptor signaling pathway : IMP:BHF-UCL VEGF-activated neuropilin signaling pathway : IMP:BHF-UCL VEGF-activated neuropilin signaling pathway involved in axon guidance : IEA:Ensembl ventral trunk neural crest cell migration : IEA:Ensembl vestibulocochlear nerve structural organization : IEA:Ensembl

^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}

Copyright © 2019 The Gliome Database
Icons made by Prosymbols, srip from www.flaticon.com