Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
O14594

Neurocan core protein (O14594)

Uniprot ID O14594
Protein Name Neurocan core protein
Gene Name NCAN
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.285
Function May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
GO - Molecular function
  • calcium ion binding : IEA:InterPro
  • carbohydrate binding : IEA:UniProtKB-KW
  • hyaluronic acid binding : IEA:UniProtKB-KW
GO - Biological process
  • cell adhesion : IEA:UniProtKB-KW
  • central nervous system development : IBA:GO_Central
  • chondroitin sulfate biosynthetic process : TAS:Reactome
  • chondroitin sulfate catabolic process : TAS:Reactome
  • dermatan sulfate biosynthetic process : TAS:Reactome
  • extracellular matrix organization : TAS:Reactome
  • skeletal system development : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.