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O14511

Pro-neuregulin-2, membrane-bound isoform (O14511)

Uniprot ID O14511
Protein Name Pro-neuregulin-2, membrane-bound isoform
Gene Name NRG2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.029
Function Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
GO - Molecular function
  • growth factor activity : IEA:UniProtKB-KW
  • signaling receptor binding : IBA:GO_Central
GO - Biological process
  • ERBB2 signaling pathway : TAS:Reactome
  • intracellular signal transduction : IBA:GO_Central
  • MAPK cascade : TAS:Reactome
  • nervous system development : IEA:InterPro
  • positive regulation of protein kinase B signaling : TAS:Reactome
  • regulation of cell motility : TAS:Reactome
  • signal transduction : TAS:ProtInc
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.