Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
O08557

N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (O08557)

Uniprot ID O08557
Protein Name N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Gene Name Ddah1
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. .
GO - Molecular function
  • amino acid binding : IDA:RGD
  • dimethylargininase activity : IDA:RGD
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines : IBA:GO_Central
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • arginine catabolic process : ISO:RGD
  • arginine metabolic process : IDA:RGD
  • citrulline metabolic process : ISS:UniProtKB
  • negative regulation of cell population proliferation : ISO:RGD
  • negative regulation of cellular response to hypoxia : ISO:RGD
  • negative regulation of vascular permeability : ISO:RGD
  • positive regulation of angiogenesis : IMP:RGD
  • positive regulation of nitric oxide biosynthetic process : IMP:RGD
  • regulation of systemic arterial blood pressure : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.