| Signal peptide(a) |
N |
Secretome P(b) |
0.361 |
| Function |
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). . |
| GO - Molecular function |
- cytoskeletal adaptor activity : NAS:UniProtKB
- frizzled binding : IPI:BHF-UCL
- identical protein binding : IPI:IntAct
- interleukin-5 receptor binding : ISS:UniProtKB
- phosphatidylinositol-4,5-bisphosphate binding : IDA:UniProtKB
- protein heterodimerization activity : IPI:UniProtKB
- protein N-terminus binding : IPI:UniProtKB
- syndecan binding : IPI:UniProtKB
|
| GO - Biological process |
- actin cytoskeleton organization : NAS:UniProtKB
- chemical synaptic transmission : NAS:UniProtKB
- ephrin receptor signaling pathway : TAS:Reactome
- intracellular signal transduction : NAS:UniProtKB
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process : IMP:UniProtKB
- negative regulation of receptor internalization : IMP:UniProtKB
- neutrophil degranulation : TAS:Reactome
- positive regulation of cell growth : IMP:UniProtKB
- positive regulation of cell migration : IMP:UniProtKB
- positive regulation of cell proliferation : IMP:UniProtKB
- positive regulation of epithelial to mesenchymal transition : IMP:UniProtKB
- positive regulation of exosomal secretion : IMP:UniProtKB
- positive regulation of extracellular exosome assembly : IMP:UniProtKB
- positive regulation of JNK cascade : IC:BHF-UCL
- positive regulation of pathway-restricted SMAD protein phosphorylation : IMP:UniProtKB
- positive regulation of phosphorylation : IDA:BHF-UCL
- positive regulation of transforming growth factor beta receptor signaling pathway : IMP:UniProtKB
- protein targeting to membrane : NAS:UniProtKB
- regulation of mitotic cell cycle : IMP:UniProtKB
- substrate-dependent cell migration, cell extension : NAS:UniProtKB
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