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O00391

Sulfhydryl oxidase 1 (O00391)

Uniprot ID O00391
Protein Name Sulfhydryl oxidase 1
Gene Name QSOX1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.65
Function Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277). .
GO - Molecular function
  • FAD binding : IDA:UniProtKB
  • flavin-linked sulfhydryl oxidase activity : IDA:UniProtKB
  • protein disulfide isomerase activity : IDA:UniProtKB
GO - Biological process
  • cell redox homeostasis : IEA:InterPro
  • cellular protein metabolic process : TAS:Reactome
  • extracellular matrix assembly : IMP:UniProtKB
  • negative regulation of macroautophagy : IMP:CACAO
  • neutrophil degranulation : TAS:Reactome
  • platelet degranulation : TAS:Reactome
  • post-translational protein modification : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.