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O00233

26S proteasome non-ATPase regulatory subunit 9 (O00233)

Uniprot ID O00233
Protein Name 26S proteasome non-ATPase regulatory subunit 9
Gene Name PSMD9
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.776
Function Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process. .
GO - Molecular function
  • bHLH transcription factor binding : ISS:BHF-UCL
  • transcription coactivator activity : ISS:BHF-UCL
GO - Biological process
  • negative regulation of insulin secretion : ISS:BHF-UCL
  • positive regulation of insulin secretion : ISS:BHF-UCL
  • positive regulation of transcription, DNA-templated : ISS:BHF-UCL
  • post-translational protein modification : TAS:Reactome
  • proteasome regulatory particle assembly : IMP:UniProtKB
  • protein deubiquitination : TAS:Reactome
  • ubiquitin-dependent protein catabolic process : NAS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.