| Signal peptide(a) |
N |
Secretome P(b) |
0.501 |
| Function |
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. .Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity). {ECO:0000250}. |
| GO - Molecular function |
- actin filament binding : IEA:Ensembl
- actin-dependent ATPase activity : IEA:Ensembl
- ATP binding : IEA:UniProtKB-KW
- calmodulin binding : IEA:UniProtKB-KW
- microfilament motor activity : IEA:Ensembl
- microtubule binding : IEA:InterPro
- microtubule motor activity : IEA:InterPro
- protein C-terminus binding : IEA:Ensembl
- Ral GTPase binding : IPI:UniProtKB
- signaling receptor binding : IPI:UniProtKB
|
| GO - Biological process |
- cellular response to interferon-gamma : IEA:Ensembl
- Fc-gamma receptor signaling pathway involved in phagocytosis : TAS:Reactome
- microtubule-based movement : IEA:InterPro
- mRNA transport : IEA:UniProtKB-KW
- positive regulation of actin filament polymerization : IEA:Ensembl
- positive regulation of cell migration : IMP:UniProtKB
- positive regulation of cell migration by vascular endothelial growth factor signaling pathway : IMP:UniProtKB
- positive regulation of cellular response to insulin stimulus : IEA:Ensembl
- positive regulation of gene expression, epigenetic : TAS:Reactome
- positive regulation of protein targeting to membrane : IMP:UniProtKB
- positive regulation of vascular endothelial growth factor signaling pathway : IMP:UniProtKB
- protein targeting : IDA:UniProtKB
- protein targeting to membrane : IDA:UniProtKB
- regulation of bicellular tight junction assembly : IMP:UniProtKB
- vesicle transport along actin filament : IEA:Ensembl
|