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O00151

PDZ and LIM domain protein 1 (O00151)

Uniprot ID O00151
Protein Name PDZ and LIM domain protein 1
Gene Name PDLIM1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.606
Function Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). .
GO - Molecular function
  • cadherin binding involved in cell-cell adhesion : HDA:BHF-UCL
  • metal ion binding : IEA:UniProtKB-KW
  • transcription coactivator activity : IEA:Ensembl
GO - Biological process
  • regulation of transcription, DNA-templated : IEA:Ensembl
  • response to hypoxia : IEA:Ensembl
  • response to oxidative stress : TAS:ProtInc
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.