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O00115

Deoxyribonuclease-2-alpha (O00115)

Uniprot ID O00115
Protein Name Deoxyribonuclease-2-alpha
Gene Name DNASE2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.735
Function Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
GO - Molecular function
  • deoxyribonuclease II activity : IBA:GO_Central
  • DNA binding : TAS:ProtInc
GO - Biological process
  • apoptotic DNA fragmentation : IBA:GO_Central
  • DNA metabolic process : TAS:ProtInc
  • erythrocyte differentiation : IEA:Ensembl
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.