Filamin A (C0JPT7)

Uniprot ID	C0JPT7
Protein Name	Filamin A
Gene Name	Flna
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	N	Secretome P^(b)
Function
GO - Molecular function	actin filament binding : ISO:RGD Fc-gamma receptor I complex binding : ISO:RGD G protein-coupled receptor binding : ISO:RGD GTPase binding : ISO:RGD ion channel binding : ISO:RGD kinase binding : ISO:RGD mu-type opioid receptor binding : IMP:RGD potassium channel regulator activity : ISO:RGD protein homodimerization activity : ISO:RGD protein kinase C binding : ISO:RGD protein-containing complex binding : IPI:RGD Rac GTPase binding : ISO:RGD Ral GTPase binding : ISO:RGD Rho GTPase binding : ISO:RGD SMAD binding : IPI:RGD small GTPase binding : ISO:RGD transcription factor binding : ISO:RGD
GO - Biological process	actin crosslink formation : ISO:RGD actin cytoskeleton organization : ISO:RGD actin cytoskeleton reorganization : ISO:RGD adenylate cyclase-inhibiting dopamine receptor signaling pathway : ISO:RGD angiogenesis : ISO:RGD blood vessel remodeling : ISO:RGD cell-cell junction organization : ISO:RGD cerebral cortex development : IEP:RGD cilium assembly : ISO:RGD cytoplasmic sequestering of protein : ISO:RGD early endosome to late endosome transport : ISO:RGD epithelial to mesenchymal transition : ISO:RGD establishment of protein localization : ISO:RGD establishment of Sertoli cell barrier : IMP:RGD formation of radial glial scaffolds : IMP:RGD heart morphogenesis : ISO:RGD mitotic spindle assembly : ISO:RGD mRNA transcription by RNA polymerase II : IMP:RGD negative regulation of apoptotic process : ISO:RGD negative regulation of DNA-binding transcription factor activity : ISO:RGD negative regulation of neuron projection development : ISO:RGD negative regulation of protein catabolic process : ISO:RGD negative regulation of transcription by RNA polymerase I : ISO:RGD positive regulation of actin filament bundle assembly : IMP:RGD positive regulation of integrin-mediated signaling pathway : ISO:RGD positive regulation of neural precursor cell proliferation : IMP:RGD positive regulation of neuron migration : IMP:RGD positive regulation of potassium ion transmembrane transport : ISO:RGD positive regulation of protein import into nucleus : ISO:RGD positive regulation of substrate adhesion-dependent cell spreading : ISO:RGD protein localization to bicellular tight junction : IMP:RGD protein localization to cell surface : ISO:RGD protein localization to plasma membrane : ISO:RGD protein stabilization : ISO:RGD receptor clustering : ISO:RGD regulation of actin filament bundle assembly : ISO:RGD regulation of cell migration : ISO:RGD regulation of membrane repolarization during cardiac muscle cell action potential : ISO:RGD semaphorin-plexin signaling pathway : ISO:RGD synapse organization : ISO:RGD tubulin deacetylation : IEA:Ensembl wound healing, spreading of cells : ISO:RGD

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}