| Signal peptide(a) |
Y |
Secretome P(b) |
0.358 |
| Function |
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades. . |
| GO - Molecular function |
- fibroblast growth factor binding : ISO:MGI
- integrin binding : ISS:UniProtKB
- phosphatase activity : ISS:UniProtKB
- protein tyrosine phosphatase activity : IMP:UniProtKB
|
| GO - Biological process |
- axonal fasciculation : ISO:MGI
- axonogenesis : IDA:MGI
- hematopoietic progenitor cell differentiation : IMP:MGI
- learning or memory : IMP:UniProtKB
- negative regulation of cell population proliferation : ISO:MGI
- negative regulation of cell-substrate adhesion : ISO:MGI
- negative regulation of dendrite development : ISO:MGI
- negative regulation of neuron apoptotic process : IDA:UniProtKB
- oligodendrocyte differentiation : IMP:UniProtKB
- peptidyl-tyrosine dephosphorylation : IMP:UniProtKB
- positive regulation of cell migration : ISO:MGI
- positive regulation of dendrite development : ISO:MGI
- positive regulation of fibroblast proliferation : ISO:MGI
- positive regulation of neuron death : ISO:MGI
- positive regulation of neuron migration : ISO:MGI
- positive regulation of neuron projection development : ISO:MGI
- positive regulation of oligodendrocyte differentiation : ISS:UniProtKB
- positive regulation of peptidyl-tyrosine phosphorylation : ISO:MGI
- positive regulation of Schwann cell migration : ISO:MGI
- protein dephosphorylation : ISO:MGI
- regulation of dendrite morphogenesis : ISO:MGI
- regulation of myelination : IMP:UniProtKB
- regulation of oligodendrocyte progenitor proliferation : IMP:UniProtKB
|