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B0BNA5

Coactosin-like protein (B0BNA5)

Uniprot ID B0BNA5
Protein Name Coactosin-like protein
Gene Name Cotl1
Species Rattus norvegicus (Rat)
Basic Information Experiments (3) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (By similarity). .
GO - Molecular function
  • actin binding : ISO:RGD
  • actin filament binding : IBA:GO_Central
  • enzyme binding : ISO:RGD
GO - Biological process
  • defense response to fungus : ISO:RGD
  • regulation of actin filament polymerization : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.