U4/U6.U5 tri-snRNP-associated protein 1 (Q9Z315)

Uniprot ID Q9Z315
Protein Name U4/U6.U5 tri-snRNP-associated protein 1
Gene Name Sart1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.492
Function Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Appears to play a role in hypoxia-induced regulation of EPO gene expression. .
GO - Molecular function
GO - Biological process
  • maturation of 5S rRNA : IBA:GO_Central
  • mRNA cis splicing, via spliceosome : IBA:GO_Central
  • mRNA splicing, via spliceosome : ISO:MGI
  • positive regulation of cytotoxic T cell differentiation : ISO:MGI
  • spliceosomal snRNP assembly : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.