| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:25628567). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (By similarity). . |
| GO - Molecular function |
- anion channel activity : IDA:RGD
- calcium channel activity : TAS:Reactome
- identical protein binding : ISO:RGD
- ion channel binding : ISO:RGD
- nucleotide binding : IEA:UniProtKB-KW
- porin activity : IEA:UniProtKB-KW
- protein kinase binding : ISO:RGD
- protein-containing complex binding : IDA:RGD
- voltage-gated anion channel activity : IDA:RGD
|
| GO - Biological process |
- anion transport : ISO:RGD
- apoptotic process : ISS:UniProtKB
- behavioral fear response : ISO:RGD
- chemical synaptic transmission : ISO:RGD
- epithelial cell differentiation : ISO:RGD
- learning : ISO:RGD
- mitochondrial calcium ion transmembrane transport : IDA:RGD
- negative regulation of reactive oxygen species metabolic process : ISO:RGD
- neuron-neuron synaptic transmission : ISO:RGD
- regulation of autophagy of mitochondrion : ISO:RGD
|