Y-box-binding protein 2 (Q9Z2C8)

Uniprot ID Q9Z2C8
Protein Name Y-box-binding protein 2
Gene Name Ybx2
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.0
Function Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay. .
GO - Molecular function
  • chromatin binding : IDA:MGI
  • DNA binding : IEA:UniProtKB-KW
  • lipid binding : IDA:MGI
  • mRNA 3'-UTR binding : IDA:MGI
  • mRNA binding : IDA:MGI
  • ribonucleoprotein complex binding : IDA:MGI
  • translation regulator activity : IDA:MGI
GO - Biological process
  • mRNA stabilization : IMP:MGI
  • negative regulation of binding : IMP:MGI
  • negative regulation of translation : IDA:MGI
  • oogenesis : IMP:MGI
  • regulation of transcription, DNA-templated : IEA:InterPro
  • spermatid development : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.