Ribosomal protein S6 kinase alpha-4 (Q9Z2B9)

Uniprot ID Q9Z2B9
Protein Name Ribosomal protein S6 kinase alpha-4
Gene Name Rps6ka4
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.449
Function Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen-and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). .
GO - Molecular function
  • ATP binding : ISS:UniProtKB
  • magnesium ion binding : IEA:InterPro
  • protein serine/threonine kinase activity : ISS:UniProtKB
GO - Biological process
  • histone H3-S10 phosphorylation : ISS:UniProtKB
  • histone H3-S28 phosphorylation : ISS:UniProtKB
  • inflammatory response : IEA:UniProtKB-KW
  • interleukin-1-mediated signaling pathway : ISO:MGI
  • intracellular signal transduction : ISS:UniProtKB
  • positive regulation of histone acetylation : ISO:MGI
  • positive regulation of histone phosphorylation : ISO:MGI
  • positive regulation of transcription by RNA polymerase II : ISO:MGI
  • protein phosphorylation : ISS:UniProtKB
  • regulation of transcription, DNA-templated : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.