| Signal peptide(a) |
Y |
Secretome P(b) |
0.591 |
| Function |
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:15563542, PubMed:18065526). Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (By similarity). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone (PubMed:19187398). . |
| GO - Molecular function |
- ATPase binding : ISO:MGI
- ion channel activity : IEA:InterPro
- ion channel binding : ISS:BHF-UCL
- myosin binding : ISO:MGI
- sodium channel regulator activity : IMP:BHF-UCL
|
| GO - Biological process |
- negative regulation of protein glutathionylation : ISS:UniProtKB
- positive regulation of inorganic anion transmembrane transport : ISO:MGI
- positive regulation of organic acid transport : ISO:MGI
- positive regulation of sodium ion export across plasma membrane : IMP:BHF-UCL
- potassium ion transport : IEA:UniProtKB-KW
- regulation of cardiac muscle cell contraction : ISO:MGI
- regulation of cardiac muscle cell membrane potential : IMP:BHF-UCL
- regulation of cytosolic calcium ion concentration : ISO:MGI
- regulation of sodium ion transmembrane transporter activity : IMP:BHF-UCL
- sodium ion transport : IEA:UniProtKB-KW
|