Signal peptide(a) |
Y |
Secretome P(b) |
|
Function |
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. . |
GO - Molecular function |
- alpha-catenin binding : ISO:RGD
- beta-catenin binding : IPI:RGD
- cadherin binding : IBA:GO_Central
- calcium ion binding : ISS:UniProtKB
- cytoskeletal protein binding : IBA:GO_Central
- enzyme binding : ISO:RGD
- gamma-catenin binding : ISO:RGD
- identical protein binding : ISO:RGD
- nitric-oxide synthase binding : IPI:RGD
- protein kinase binding : IPI:RGD
- protein phosphatase binding : ISO:RGD
- protein-containing complex binding : IPI:RGD
|
GO - Biological process |
- adherens junction organization : IBA:GO_Central
- blood vessel morphogenesis : ISO:RGD
- brain development : IBA:GO_Central
- brain morphogenesis : ISO:RGD
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules : IMP:RGD
- cell adhesion : ISO:RGD
- cell migration : ISO:RGD
- cell morphogenesis : IBA:GO_Central
- cell-cell adhesion : IDA:RGD
- cell-cell adhesion mediated by cadherin : ISS:UniProtKB
- cell-cell junction assembly : IBA:GO_Central
- cerebral cortex development : ISO:RGD
- glial cell differentiation : ISS:UniProtKB
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : ISO:RGD
- homeostasis of number of cells : ISO:RGD
- homophilic cell adhesion via plasma membrane adhesion molecules : ISO:RGD
- modulation of chemical synaptic transmission : EXP:SynGO
- multicellular organism development : IBA:GO_Central
- negative regulation of canonical Wnt signaling pathway : ISO:RGD
- neuroepithelial cell differentiation : ISO:RGD
- neuroligin clustering involved in postsynaptic membrane assembly : ISO:RGD
- neuronal stem cell population maintenance : ISS:UniProtKB
- positive regulation of MAPK cascade : ISO:RGD
- positive regulation of synaptic vesicle clustering : ISO:RGD
- protein localization to plasma membrane : ISO:RGD
- radial glial cell differentiation : ISO:RGD
- regulation of axonogenesis : IMP:RGD
- regulation of myelination : IMP:RGD
- regulation of oligodendrocyte progenitor proliferation : ISO:RGD
- regulation of postsynaptic density protein 95 clustering : ISO:RGD
- regulation of protein localization : IMP:RGD
- regulation of Rho protein signal transduction : IMP:RGD
- regulation of synaptic transmission, glutamatergic : IMP:SynGO
- striated muscle cell differentiation : ISO:RGD
- synapse assembly : IMP:RGD
- synaptic membrane adhesion : IC:SynGO
- telencephalon development : ISO:RGD
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