Cadherin-2 (Q9Z1Y3)

Uniprot ID Q9Z1Y3
Protein Name Cadherin-2
Gene Name Cdh2
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. .
GO - Molecular function
  • alpha-catenin binding : ISO:RGD
  • beta-catenin binding : IPI:RGD
  • cadherin binding : IBA:GO_Central
  • calcium ion binding : ISS:UniProtKB
  • cytoskeletal protein binding : IBA:GO_Central
  • enzyme binding : ISO:RGD
  • gamma-catenin binding : ISO:RGD
  • identical protein binding : ISO:RGD
  • nitric-oxide synthase binding : IPI:RGD
  • protein kinase binding : IPI:RGD
  • protein phosphatase binding : ISO:RGD
  • protein-containing complex binding : IPI:RGD
GO - Biological process
  • adherens junction organization : IBA:GO_Central
  • blood vessel morphogenesis : ISO:RGD
  • brain development : IBA:GO_Central
  • brain morphogenesis : ISO:RGD
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules : IMP:RGD
  • cell adhesion : ISO:RGD
  • cell migration : ISO:RGD
  • cell morphogenesis : IBA:GO_Central
  • cell-cell adhesion : IDA:RGD
  • cell-cell adhesion mediated by cadherin : ISS:UniProtKB
  • cell-cell junction assembly : IBA:GO_Central
  • cerebral cortex development : ISO:RGD
  • glial cell differentiation : ISS:UniProtKB
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : ISO:RGD
  • homeostasis of number of cells : ISO:RGD
  • homophilic cell adhesion via plasma membrane adhesion molecules : ISO:RGD
  • modulation of chemical synaptic transmission : EXP:SynGO
  • multicellular organism development : IBA:GO_Central
  • negative regulation of canonical Wnt signaling pathway : ISO:RGD
  • neuroepithelial cell differentiation : ISO:RGD
  • neuroligin clustering involved in postsynaptic membrane assembly : ISO:RGD
  • neuronal stem cell population maintenance : ISS:UniProtKB
  • positive regulation of MAPK cascade : ISO:RGD
  • positive regulation of synaptic vesicle clustering : ISO:RGD
  • protein localization to plasma membrane : ISO:RGD
  • radial glial cell differentiation : ISO:RGD
  • regulation of axonogenesis : IMP:RGD
  • regulation of myelination : IMP:RGD
  • regulation of oligodendrocyte progenitor proliferation : ISO:RGD
  • regulation of postsynaptic density protein 95 clustering : ISO:RGD
  • regulation of protein localization : IMP:RGD
  • regulation of Rho protein signal transduction : IMP:RGD
  • regulation of synaptic transmission, glutamatergic : IMP:SynGO
  • striated muscle cell differentiation : ISO:RGD
  • synapse assembly : IMP:RGD
  • synaptic membrane adhesion : IC:SynGO
  • telencephalon development : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.