| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation (PubMed:21317537, PubMed:23542070). . |
| GO - Molecular function |
- ATP binding : IEA:UniProtKB-KW
- kinase activity : ISO:MGI
- protein kinase activity : IDA:MGI
- protein kinase binding : ISO:MGI
- protein serine/threonine kinase activity : IGI:ParkinsonsUK-UCL
|
| GO - Biological process |
- activation of MAPK activity : ISS:UniProtKB
- activation of protein kinase activity : IBA:GO_Central
- cellular hypotonic response : IGI:ParkinsonsUK-UCL
- intracellular signal transduction : IGI:ParkinsonsUK-UCL
- ion homeostasis : IMP:MGI
- maintenance of lens transparency : IMP:ParkinsonsUK-UCL
- negative regulation of creatine transmembrane transporter activity : ISO:MGI
- negative regulation of pancreatic juice secretion : IMP:UniProtKB
- negative regulation of potassium ion transmembrane transport : IDA:MGI
- negative regulation of potassium ion transmembrane transporter activity : IGI:ParkinsonsUK-UCL
- negative regulation of protein phosphorylation : IDA:MGI
- negative regulation of sodium ion transmembrane transporter activity : ISO:MGI
- peptidyl-serine phosphorylation : ISO:MGI
- peptidyl-threonine phosphorylation : IGI:ParkinsonsUK-UCL
- positive regulation of ion transmembrane transporter activity : ISO:MGI
- positive regulation of potassium ion transport : ISO:MGI
- protein autophosphorylation : ISS:UniProtKB
- protein phosphorylation : ISO:MGI
- regulation of apoptotic process : IBA:GO_Central
- regulation of blood pressure : IMP:MGI
- regulation of inflammatory response : IDA:MGI
- regulation of mitotic cell cycle : IBA:GO_Central
- signal transduction by protein phosphorylation : ISO:MGI
- signal transduction by trans-phosphorylation : ISO:MGI
- stress-activated protein kinase signaling cascade : IBA:GO_Central
|