Growth/differentiation factor 11 (Q9Z1W4)

Uniprot ID	Q9Z1W4
Protein Name	Growth/differentiation factor 11
Gene Name	Gdf11
Species	Mus musculus (Mouse)

Signal peptide^(a)	Y	Secretome P^(b)	0.911
Function	Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development (PubMed:10391213). May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:16845371, PubMed:12414726). .
GO - Molecular function	cytokine activity : IBA:GO_Central growth factor activity : IEA:UniProtKB-KW transforming growth factor beta receptor binding : IBA:GO_Central
GO - Biological process	animal organ morphogenesis : IMP:MGI anterior/posterior pattern specification : IMP:MGI camera-type eye morphogenesis : IMP:MGI cell maturation : IMP:MGI metanephros development : IDA:MGI negative regulation of cell differentiation : IDA:MGI negative regulation of cell proliferation : IMP:MGI negative regulation of neuron differentiation : ISO:MGI pancreas development : IMP:MGI positive regulation of pathway-restricted SMAD protein phosphorylation : IBA:GO_Central regulation of apoptotic process : IBA:GO_Central regulation of MAPK cascade : IBA:GO_Central roof of mouth development : IGI:MGI skeletal system development : IGI:MGI SMAD protein signal transduction : IDA:UniProtKB spinal cord anterior/posterior patterning : IMP:MGI ureteric bud development : IMP:MGI

^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}

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