1-phosphatidylinositol 3-phosphate 5-kinase (Q9Z1T6)

Uniprot ID Q9Z1T6
Protein Name 1-phosphatidylinositol 3-phosphate 5-kinase
Gene Name Pikfyve
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.373
Function The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole. .
GO - Molecular function
  • 1-phosphatidylinositol-3-phosphate 5-kinase activity : IBA:GO_Central
  • 1-phosphatidylinositol-4-phosphate 5-kinase activity : IDA:UniProtKB
  • 1-phosphatidylinositol-5-kinase activity : TAS:Reactome
  • ATP binding : IEA:UniProtKB-KW
  • zinc ion binding : IDA:UniProtKB
GO - Biological process
  • intracellular signal transduction : IDA:UniProtKB
  • myelin assembly : IGI:MGI
  • protein localization to nucleus : ISO:MGI
  • regulation of autophagosome assembly : ISO:MGI
  • retrograde transport, endosome to Golgi : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.