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Q9Z1Q5

Chloride intracellular channel protein 1 (Q9Z1Q5)

Uniprot ID Q9Z1Q5
Protein Name Chloride intracellular channel protein 1
Gene Name Clic1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.648
Function Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity). .
GO - Molecular function
  • cadherin binding : ISO:MGI
  • chloride channel activity : ISO:MGI
  • voltage-gated ion channel activity : IEA:UniProtKB-KW
GO - Biological process
  • chloride transmembrane transport : IBA:GO_Central
  • chloride transport : ISO:MGI
  • positive regulation of osteoblast differentiation : IDA:MGI
  • regulation of cell cycle : IEA:InterPro
  • regulation of ion transmembrane transport : IEA:UniProtKB-KW
  • regulation of mitochondrial membrane potential : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.