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Q9Z126

Platelet factor 4 (Q9Z126)

Uniprot ID Q9Z126
Protein Name Platelet factor 4
Gene Name Pf4
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) Y Secretome P(b) 0.905
Function Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity). .
GO - Molecular function
  • chemokine activity : IBA:GO_Central
  • CXCR chemokine receptor binding : IBA:GO_Central
  • CXCR3 chemokine receptor binding : ISS:UniProtKB
  • heparin binding : ISS:UniProtKB
GO - Biological process
  • antimicrobial humoral immune response mediated by antimicrobial peptide : IMP:UniProtKB
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • cytokine-mediated signaling pathway : ISS:UniProtKB
  • defense response to protozoan : IMP:UniProtKB
  • G-protein coupled receptor signaling pathway : IBA:GO_Central
  • immune response : ISO:MGI
  • inflammatory response : IBA:GO_Central
  • killing by host of symbiont cells : ISO:MGI
  • leukocyte chemotaxis : ISS:UniProtKB
  • negative regulation of angiogenesis : ISS:UniProtKB
  • negative regulation of cytolysis : ISO:MGI
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : ISO:MGI
  • negative regulation of megakaryocyte differentiation : ISS:UniProtKB
  • negative regulation of MHC class II biosynthetic process : ISO:MGI
  • platelet activation : ISS:UniProtKB
  • positive regulation of cAMP metabolic process : ISS:UniProtKB
  • positive regulation of cAMP-mediated signaling : ISS:UniProtKB
  • positive regulation of gene expression : ISO:MGI
  • positive regulation of macrophage derived foam cell differentiation : ISO:MGI
  • positive regulation of macrophage differentiation : ISO:MGI
  • positive regulation of neutrophil chemotaxis : IBA:GO_Central
  • positive regulation of transcription by RNA polymerase II : ISS:UniProtKB
  • positive regulation of tumor necrosis factor production : ISO:MGI
  • protein-containing complex assembly : ISO:MGI
  • regulation of cell proliferation : ISS:UniProtKB
  • response to lipopolysaccharide : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.