Signal peptide(a) |
Y |
Secretome P(b) |
|
Function |
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. . |
GO - Molecular function |
- protein homodimerization activity : ISO:RGD
- thioredoxin peroxidase activity : IBA:GO_Central
|
GO - Biological process |
- 4-hydroxyproline metabolic process : ISO:RGD
- cell redox homeostasis : ISO:RGD
- extracellular matrix organization : ISO:RGD
- male gonad development : ISO:RGD
- negative regulation of male germ cell proliferation : ISO:RGD
- oxidation-reduction process : ISO:RGD
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline : IEA:Ensembl
- protein maturation by protein folding : ISO:RGD
- reactive oxygen species metabolic process : ISO:RGD
- response to oxidative stress : IBA:GO_Central
- spermatogenesis : ISO:RGD
|