Peroxiredoxin-4 (Q9Z0V5)

Uniprot ID Q9Z0V5
Protein Name Peroxiredoxin-4
Gene Name Prdx4
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. .
GO - Molecular function
  • protein homodimerization activity : ISO:RGD
  • thioredoxin peroxidase activity : IBA:GO_Central
GO - Biological process
  • 4-hydroxyproline metabolic process : ISO:RGD
  • cell redox homeostasis : ISO:RGD
  • extracellular matrix organization : ISO:RGD
  • male gonad development : ISO:RGD
  • negative regulation of male germ cell proliferation : ISO:RGD
  • oxidation-reduction process : ISO:RGD
  • peptidyl-proline hydroxylation to 4-hydroxy-L-proline : IEA:Ensembl
  • protein maturation by protein folding : ISO:RGD
  • reactive oxygen species metabolic process : ISO:RGD
  • response to oxidative stress : IBA:GO_Central
  • spermatogenesis : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.