Suppressor of fused homolog (Q9Z0P7 )

Uniprot ID	Q9Z0P7
Protein Name	Suppressor of fused homolog
Gene Name	Sufu
Species	Mus musculus (Mouse)

Signal peptide^(a)	N	Secretome P^(b)
Function	Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:16155214, PubMed:16459298). Down-regulates GLI1-mediated transactivation of target genes (PubMed:11960000). Part of a corepressor complex that acts on DNA-bound GLI1 (PubMed:11960000). May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (By similarity). Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10531011, PubMed:16459298). Negative regulator of beta-catenin signaling (PubMed:11477086). Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL) (PubMed:10531011, PubMed:20360384). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state (PubMed:10531011, PubMed:20360384). Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R (PubMed:10531011, PubMed:20360384). When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A) (PubMed:10531011, PubMed:20360384). Required for normal embryonic development (PubMed:16155214, PubMed:16459298). Required for the proper formation of hair follicles and the control of epidermal differentiation (PubMed:16155214, PubMed:16459298, PubMed:23034632). .
GO - Molecular function	beta-catenin binding : IDA:MGI protein kinase binding : ISO:MGI transcription factor binding : ISO:MGI
GO - Biological process	aorta development : IMP:MGI coronary vasculature development : IMP:MGI cytoplasmic sequestering of transcription factor : IGI:MGI determination of left/right symmetry : IMP:MGI heart looping : IMP:MGI negative regulation of DNA-binding transcription factor activity : IBA:GO_Central negative regulation of smoothened signaling pathway : IDA:MGI negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning : IMP:MGI negative regulation of transcription by RNA polymerase II : IDA:MGI negative regulation of ubiquitin-dependent protein catabolic process : IGI:MGI neural tube closure : IMP:MGI skin development : IMP:MGI smoothened signaling pathway : IMP:MGI smoothened signaling pathway involved in spinal cord motor neuron cell fate specification : IMP:MGI smoothened signaling pathway involved in ventral spinal cord interneuron specification : IMP:MGI spinal cord dorsal/ventral patterning : IMP:MGI ventricular septum development : IMP:MGI

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}