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Q9Y625

Glypican-6 (Q9Y625)

Uniprot ID Q9Y625
Protein Name Glypican-6
Gene Name GPC6
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.628
Function Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling. .
GO - Molecular function
  • coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway : NAS:ParkinsonsUK-UCL
GO - Biological process
  • cell migration : IDA:UniProtKB
  • glycosaminoglycan biosynthetic process : TAS:Reactome
  • glycosaminoglycan catabolic process : TAS:Reactome
  • regulation of neurotransmitter receptor localization to postsynaptic specialization membrane : IBA:GO_Central
  • regulation of presynapse assembly : IBA:GO_Central
  • regulation of protein localization to membrane : IBA:GO_Central
  • regulation of signal transduction : IEA:InterPro
  • retinoid metabolic process : TAS:Reactome
  • synaptic membrane adhesion : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.