Intraflagellar transport protein 25 homolog (Q9Y547)

Uniprot ID Q9Y547
Protein Name Intraflagellar transport protein 25 homolog
Gene Name HSPB11
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.879
Function Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity). .
GO - Molecular function
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • cell differentiation : IEA:UniProtKB-KW
  • heart development : IEA:Ensembl
  • intraciliary transport involved in cilium assembly : TAS:Reactome
  • kidney development : ISS:UniProtKB
  • left/right axis specification : IEA:Ensembl
  • lung development : IEA:Ensembl
  • skeletal system development : IEA:Ensembl
  • smoothened signaling pathway : IEA:Ensembl
  • spermatogenesis : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.