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Q9Y4L1

Hypoxia up-regulated protein 1 (Q9Y4L1)

Uniprot ID Q9Y4L1
Protein Name Hypoxia up-regulated protein 1
Gene Name HYOU1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.0
Function Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • chaperone binding : ISS:ParkinsonsUK-UCL
GO - Biological process
  • cellular response to hypoxia : IDA:ParkinsonsUK-UCL
  • ER to Golgi vesicle-mediated transport : IDA:ParkinsonsUK-UCL
  • IRE1-mediated unfolded protein response : TAS:Reactome
  • negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway : IEA:Ensembl
  • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway : IDA:ParkinsonsUK-UCL
  • receptor-mediated endocytosis : TAS:Reactome
  • response to endoplasmic reticulum stress : IEP:ParkinsonsUK-UCL
  • response to ischemia : ISS:ParkinsonsUK-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.