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Q9WVI9

C-Jun-amino-terminal kinase-interacting protein 1 (Q9WVI9 )

Uniprot ID Q9WVI9
Protein Name C-Jun-amino-terminal kinase-interacting protein 1
Gene Name Mapk8ip1
Species Mus musculus (Mouse)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response (By similarity). Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells (PubMed:23963642). .
GO - Molecular function
  • identical protein binding : ISO:MGI
  • JUN kinase binding : ISO:MGI
  • kinesin binding : IPI:UniProtKB
  • MAP-kinase scaffold activity : ISO:MGI
  • mitogen-activated protein kinase kinase binding : ISO:MGI
  • mitogen-activated protein kinase kinase kinase binding : ISO:MGI
  • protein kinase binding : IPI:UniProtKB
GO - Biological process
  • JUN phosphorylation : IDA:MGI
  • negative regulation of apoptotic process : ISO:MGI
  • negative regulation of canonical Wnt signaling pathway : IBA:GO_Central
  • negative regulation of intrinsic apoptotic signaling pathway : IDA:MGI
  • negative regulation of JNK cascade : ISO:MGI
  • negative regulation of JUN kinase activity : ISS:UniProtKB
  • positive regulation of endocytosis : IBA:GO_Central
  • positive regulation of JNK cascade : IMP:UniProtKB
  • receptor-mediated endocytosis : IBA:GO_Central
  • regulation of CD8-positive, alpha-beta T cell proliferation : IMP:UniProtKB
  • regulation of JNK cascade : IMP:UniProtKB
  • regulation of transcription, DNA-templated : IDA:MGI
  • signal transduction : IDA:MGI
  • vesicle-mediated transport : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.