Signal peptide(a) |
N |
Secretome P(b) |
0.59 |
Function |
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). . |
GO - Molecular function |
- endopeptidase inhibitor activity : ISO:MGI
- proteasome binding : ISO:MGI
- thiol-dependent ubiquitin-specific protease activity : ISS:UniProtKB
|
GO - Biological process |
- DNA recombination : IEA:UniProtKB-KW
- DNA repair : IEA:UniProtKB-KW
- forebrain morphogenesis : IMP:BHF-UCL
- lateral ventricle development : IMP:BHF-UCL
- midbrain development : IMP:BHF-UCL
- protein deubiquitination : ISS:UniProtKB
- regulation of proteasomal protein catabolic process : ISO:MGI
- regulation of transcription, DNA-templated : IEA:UniProtKB-KW
- transcription, DNA-templated : IEA:UniProtKB-KW
- ubiquitin-dependent protein catabolic process : IEA:InterPro
|