Ubiquitin carboxyl-terminal hydrolase isozyme L5 (Q9WUP7)

Uniprot ID Q9WUP7
Protein Name Ubiquitin carboxyl-terminal hydrolase isozyme L5
Gene Name Uchl5
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.59
Function Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). .
GO - Molecular function
  • endopeptidase inhibitor activity : ISO:MGI
  • proteasome binding : ISO:MGI
  • thiol-dependent ubiquitin-specific protease activity : ISS:UniProtKB
GO - Biological process
  • DNA recombination : IEA:UniProtKB-KW
  • DNA repair : IEA:UniProtKB-KW
  • forebrain morphogenesis : IMP:BHF-UCL
  • lateral ventricle development : IMP:BHF-UCL
  • midbrain development : IMP:BHF-UCL
  • protein deubiquitination : ISS:UniProtKB
  • regulation of proteasomal protein catabolic process : ISO:MGI
  • regulation of transcription, DNA-templated : IEA:UniProtKB-KW
  • transcription, DNA-templated : IEA:UniProtKB-KW
  • ubiquitin-dependent protein catabolic process : IEA:InterPro
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.