| Signal peptide(a) |
N |
Secretome P(b) |
0.636 |
| Function |
Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. .(Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077}. |
| GO - Molecular function |
- cadherin binding : HDA:BHF-UCL
- cytoskeletal protein binding : IBA:GO_Central
- identical protein binding : IPI:IntAct
- phosphatidic acid binding : IDA:UniProtKB
- phospholipid binding : IBA:GO_Central
- transporter activity : TAS:ProtInc
|
| GO - Biological process |
- actin cytoskeleton organization : TAS:ProtInc
- caveola assembly : IMP:UniProtKB
- caveolin-mediated endocytosis : IMP:UniProtKB
- cell projection morphogenesis : ISS:UniProtKB
- cytoskeleton organization : IBA:GO_Central
- membrane organization : TAS:Reactome
- modulation of chemical synaptic transmission : IEA:Ensembl
- negative regulation of endocytosis : IEA:Ensembl
- plasma membrane tubulation : IDA:UniProtKB
- protein localization to endosome : IMP:UniProtKB
|