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Q9UNA0

A disintegrin and metalloproteinase with thrombospondin motifs 5 (Q9UNA0)

Uniprot ID Q9UNA0
Protein Name A disintegrin and metalloproteinase with thrombospondin motifs 5
Gene Name ADAMTS5
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.0
Function Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection. .
GO - Molecular function
  • extracellular matrix binding : IEA:Ensembl
  • heparin binding : IEA:Ensembl
  • integrin binding : TAS:ProtInc
  • metalloendopeptidase activity : IEA:InterPro
  • metallopeptidase activity : TAS:ProtInc
  • peptidase activity : IDA:UniProtKB
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • defense response to bacterium : IEA:Ensembl
  • extracellular matrix disassembly : TAS:Reactome
  • negative regulation of cold-induced thermogenesis : ISS:YuBioLab
  • proteolysis : TAS:ProtInc
  • tooth eruption : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.